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The Alzheimer's Library
Alzheimer\'s and Mitochondria

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An update on the toxicity of Abeta in Alzheimer's disease

Votes:16 Comments:0
Alzheimer's disease is characterized histopathologically by deposition of insoluble forms of the peptide Abeta and the protein tau in brain. Abeta is the principal component of amyloid plaques and tau READ MORE
http://www.pubmedcentral.nih.gov/articlerender.fcgi...

Amyloid precursor protein and mitochondrial dysfunction in Alzheimer's disease

Votes:18 Comments:0
Growing evidence suggests that mitochondrial dysfunction is one of the key intracellular lesions associated with the pathogenesis of Alzheimer's disease (AD). Mitochondria, the powerhouses of the cell READ MORE
http://nro.sagepub.com/cgi/content/abstract/13/6/626

Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L ta...

Votes:24 Comments:0
Transgenic mice overexpressing the P301L mutant human tau protein exhibit an accumulation of hyperphosphorylated tau and develop neurofibrillary tangles. The consequences of tau pathology were investi READ MORE
http://www.jbc.org/cgi/content/full/280/25/23802...

Mitoenergetic failure in Alzheimer disease

Votes:29 Comments:1
INVITED REVIEWS Brain cells are highly energy dependent for maintaining ion homeostasis during high metabolic activity. During active periods, full mitochondrial function is essential to generate A READ MORE
http://ajpcell.physiology.org/cgi/content/full/292/1/C8
Illinois Nursing Home Library , Mesothelioma Library
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