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The Alzheimer's Library
Combination Therapies for Alzheimer\'s

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Memantine in patients with Alzheimer's disease receiving donepezil: new analyses...

Votes:36 Comments:0
Introduction Memantine and cholinesterase inhibitors potentially offer additional benefits in Alzheimer's disease (AD) when used together. This study assessed the efficacy and safety of combination READ MORE
http://alzres.com/content/5/1/6/abstract

Safety and tolerability of rivastigmine capsule with memantine in patients with ...

Votes:18 Comments:0
OBJECTIVE: Rivastigmine, a dual cholinesterase inhibitor (ChEI), is widely approved for the symptomatic treatment of both mild-to-moderate Alzheimer's disease (AD) and Parkinson's disease dementia. READ MORE
http://www.ncbi.nlm.nih.gov/pubmed/19670390

Tolerability of memantine in combination with cholinesterase inhibitors in demen...

Votes:5 Comments:0
Memantine, a moderate-affinity, uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, has been shown to be effective in dementia, including Alzheimer disease (AD). Therefore, its combination READ MORE
http://www.ncbi.nlm.nih.gov/pubmed/12598818

Long-term course and effectiveness of combination therapy in Alzheimer disease

Votes:10 Comments:0
OBJECTIVE: To compare the real-world clinical effectiveness and long-term clinical trajectory in patients with Alzheimer disease (AD) treated with combination (COMBO) therapy consisting of cholines READ MORE
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718545/

Adding memantine to rivastigmine therapy in patients with mild-to-moderate alzhe...

Votes:15 Comments:0
Objective: At present, inhibition of cholinesterase is the treatment of choice for subjects with mild-to-moderate Alzheimer's disease (AD). Memantine, a noncompetitive antagonist at N-methyl-d-asparta READ MORE
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1764534/

Persistent treatment with cholinesterase inhibitors and/or memantine slows clini...

Votes:21 Comments:0
Introduction There are no empiric data to support guidelines for duration of therapy with antidementia drugs. This study examined whether persistent use of antidementia drugs slows clinical progres READ MORE
http://alzres.com/content/1/2/7

Rivastigmine Monotherapy and Combination Therapy with Memantine in Patients with...

Votes:12 Comments:0
We investigated the efficacy and safety of rivastigmine alone and combined with memantine in Alzheimer's disease patients previously failing on donepezil or galantamine. This was a prospective, ope READ MORE
http://www.medscape.com/viewarticle/521100

Long-term effects of the concomitant use of memantine with cholinesterase inhibi...

Votes:3 Comments:0
* Background: Patients using cholinesterase inhibitors (ChEIs) have a delay in nursing home (NH) admission compared with those who were not using the medication. This study was conducted to examin READ MORE
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823571

Trial of Memantine/Donepezil Paves the Way for Combination Therapy

Votes:14 Comments:0
22 January 2004. Combining memantine with an older, widely used AD drug further improves measures of cognition, global well-being, activities of daily living, and behavior in people with moderate to s READ MORE
http://www.alzforum.org/new/detail.asp...

First long-term study finds that treatment slows symptom progression, benefits l...

Votes:22 Comments:0
Study confirms benefit of combination therapy for Alzheimer's disease Extended treatment with Alzheimer's disease drugs can significantly slow the rate at which the disorder advances, and combinati READ MORE
http://esciencenews.com/articles/2008/09/22/study.confirms.benefit.com...

Long-Term Combination Alzheimer's Therapy Slows Decline CME

Votes:19 Comments:0
Continuing Medical Education course Release Date: September 30, 2008; Valid for credit through September 30, 2009 Credits Available Physicians - maximum of 0.25 AMA PRA Category 1 Credit(s)™ for READ MORE
http://www.medscape.com/viewarticle/581273
Studies have shown that a combination of Namenda (memantine) and one of the cholinesterase inhibitors can often be more effective than either type of drug by itself. Recent clinical trials indicate Axona in combination with either or both types of medicines can be even more effective.
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