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The Alzheimer's Library
Early-Onset Familial Alzheimer\'s Disease (eFAD)

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Alzheimer's disease phenotypes and genotypes associated with mutations in presen...

Votes:35 Comments:0
Mutations in presenilin 2 are rare causes of early onset familial Alzheimer's disease. Eighteen presenilin 2 mutations have been reported, although not all have been confirmed pathogenic. Much remains READ MORE
http://brain.oxfordjournals.org/content/133/4/1143.long

Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention...

Votes:8 Comments:0
Autosomal-dominant Alzheimer's disease has provided significant understanding of the pathophysiology of Alzheimer's disease. The present review summarizes clinical, pathological, imaging, biochemical, READ MORE
http://alzres.com/content/pdf/alzrt59.pdf

Histopathological and molecular heterogeneity among individuals with dementia as...

Votes:19 Comments:0
BACKGROUND: Mutations in the presenilin (PSEN) genes are associated with early-onset familial Alzheimer's disease (FAD). Biochemical characterizations and comparisons have revealed that many PSEN muta READ MORE
http://www.molecularneurodegeneration.com/content/3/1/20

Clinical features of early-onset Alzheimer disease in a large kindred with an E2...

Votes:33 Comments:0
OBJECTIVES: To characterize clinical features of a very large pedigree with early-onset Alzheimer disease (AD) in which all affected individuals carry the identical glutamic acid-to-alanine mutation a READ MORE
http://jama.ama-assn.org/cgi/reprint/277/10/793.pdf
Hematology Library , Brain Fitness Trends
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