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The Alzheimer's Library
Frontotemporal Dementia (FTD) Pathology

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TDP-43 pathologic lesions and clinical phenotype in frontotemporal lobar degener...
Votes:5 Comments:0
ABSTRACT Background: TDP-43 is a major ubiquitinated disease protein in the pathologic condition of frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). Objective: To READ MORE
http://archneur.ama-assn.org/cgi/content/full/64/10/1449

Frequency of Alzheimer's pathology in progressive focal cortical syndromes
Votes:31 Comments:0
SUMMARY: To determine the frequency of Alzheimer's disease (AD) pathology in patients presenting with progressive focal cortical syndromes, notably posterior cortical atrophy (PCA), corticobasal synd READ MORE
http://brain.oxfordjournals.org/cgi/content/full/130/10/2636

Semantic dementia: a unique clinicopathological syndrome
Votes:10 Comments:0
Semantic dementia (SD), one of the main clinical variants of frontotemporal dementia, presents a unique combination of clinical and imaging abnormalities. We describe the epidemiological, cognitive, a READ MORE
http://www.ncbi.nlm.nih.gov/pubmed/17945154

Glucose metabolism in frontotemporal dementia (FTD)
Votes:10 Comments:0
OBJECTIVE: To identify the pattern of progression of decline of cerebral glucose metabolism in frontotemporal dementia (FTD, frontal variant). METHODS: 22 patients with mild FTD underwent 18F-FDG-posi READ MORE
http://www.ncbi.nlm.nih.gov/pubmed/16448722

Ubiquitin-positive inclusions in FTD and motor neuron disease
Votes:7 Comments:0
Frontotemporal lobar degeneration (FTLD) with tau-negative, ubiquitin-positive inclusions has been a topic of major interest in recent years, with this group now accounting for the majority of tau-neg READ MORE
http://www.ncbi.nlm.nih.gov/pubmed/16409556
The pathologies underlying the frontotemporal dementias are many and complex. Some researchers feel these disorders should be separated into at least two different groups.
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