Alzheimer's disease is characterized histopathologically by deposition of insoluble forms of the peptide Abeta and the protein tau in brain. Abeta is the principal component of amyloid plaques and tau READ MORE http://www.pubmedcentral.nih.gov/articlerender.fcgi...
Growing evidence suggests that mitochondrial dysfunction is one of the key intracellular lesions associated with the pathogenesis of Alzheimer's disease (AD). Mitochondria, the powerhouses of the cell READ MORE http://nro.sagepub.com/cgi/content/abstract/13/6/626
Transgenic mice overexpressing the P301L mutant human tau protein exhibit an accumulation of hyperphosphorylated tau and develop neurofibrillary tangles. The consequences of tau pathology were investi READ MORE http://www.jbc.org/cgi/content/full/280/25/23802...
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Brain cells are highly energy dependent for maintaining ion homeostasis during high metabolic activity. During active periods, full mitochondrial function is essential to generate A READ MORE http://ajpcell.physiology.org/cgi/content/full/292/1/C8
