Introduction
Memantine and cholinesterase inhibitors potentially offer additional benefits in Alzheimer's disease (AD) when used together. This study assessed the efficacy and safety of combination READ MORE http://alzres.com/content/5/1/6/abstract
OBJECTIVE:
Rivastigmine, a dual cholinesterase inhibitor (ChEI), is widely approved for the symptomatic treatment of both mild-to-moderate Alzheimer's disease (AD) and Parkinson's disease dementia. READ MORE http://www.ncbi.nlm.nih.gov/pubmed/19670390
Memantine, a moderate-affinity, uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, has been shown to be effective in dementia, including Alzheimer disease (AD). Therefore, its combination READ MORE http://www.ncbi.nlm.nih.gov/pubmed/12598818
OBJECTIVE:
To compare the real-world clinical effectiveness and long-term clinical trajectory in patients with Alzheimer disease (AD) treated with combination (COMBO) therapy consisting of cholines READ MORE http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718545/
Objective: At present, inhibition of cholinesterase is the treatment of choice for subjects with mild-to-moderate Alzheimer's disease (AD). Memantine, a noncompetitive antagonist at N-methyl-d-asparta READ MORE http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1764534/
Introduction
There are no empiric data to support guidelines for duration of therapy with antidementia drugs. This study examined whether persistent use of antidementia drugs slows clinical progres READ MORE http://alzres.com/content/1/2/7
We investigated the efficacy and safety of rivastigmine alone and combined with memantine in Alzheimer's disease patients previously failing on donepezil or galantamine.
This was a prospective, ope READ MORE http://www.medscape.com/viewarticle/521100
* Background: Patients using cholinesterase inhibitors (ChEIs) have a delay in nursing home (NH) admission compared with those who were not using the medication. This study was conducted to examin READ MORE http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823571
22 January 2004. Combining memantine with an older, widely used AD drug further improves measures of cognition, global well-being, activities of daily living, and behavior in people with moderate to s READ MORE http://www.alzforum.org/new/detail.asp...
Continuing Medical Education course
Release Date: September 30, 2008; Valid for credit through September 30, 2009
Credits Available
Physicians - maximum of 0.25 AMA PRA Category 1 Credit(s)™ for READ MORE http://www.medscape.com/viewarticle/581273
Studies have shown that a combination of Namenda (memantine) and one of the cholinesterase inhibitors can often be more effective than either type of drug by itself. Recent clinical trials indicate Axona in combination with either or both types of medicines can be even more effective.