Alzheimer's disease (AD) is the most common cause of dementia and represents a major public health problem. The neuropathological findings of Aβ amyloid plaques and tau containing neurofibrillary tan

Since the 1990s, the genetics of Alzheimer disease (AD) has been an active area of research. The identification of deterministic mutations in the APP, PSEN1, and PSEN2 genes responsible for early-onse