Dietary supplementation with uridine-5'-monophosphate (UMP), a membrane phosphatide precursor, increases acetylcholine level and release in striatum of aged rat
ABSTRACT The biosynthesis of brain membrane phosphatides, e.g., phosphatidylcholine (PtdCho), may utilize three circulating compounds: choline, uridine (a precursor for UTP, CTP, and CDP-choline),
Oral administration of circulating precursors for membrane phosphatides can promote the synthesis of new brain synapse
ABSTRACT Although cognitive performance in humans and experimental animals can be improved by administering the omega-3 fatty acid docosahexaenoic acid (DHA), the neurochemical mechanisms underlyin
Oral Supplementation with Docosahexaenoic Acid and Uridine-5'-Monophosphate Increases Dendritic Spine Density in Adult Gerbil Hippocampus
ABSTRACT Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, is an essential component of membrane phosphatides and has been implicated in cognitive functions. Low levels of circulat